Fig. 8: The effects of oxytocin and oxytocin receptor antagonists on mice’s social ability and social novelty. | Communications Biology

Fig. 8: The effects of oxytocin and oxytocin receptor antagonists on mice’s social ability and social novelty.

From: Oxytocin in periaqueductal gray plasticly regulates strain-dependent social recognition memory in mice, modeling social identity

Fig. 8

A Schematic of the behavioral paradigm for the three-chamber social test to assess sociability and social novelty in mice. B Statistical analysis of interaction times between the test mouse and an empty cage (Empty cage, E) and a novel mouse (Novel mouse, N) (n = 6). Oxytocin and oxytocin receptor antagonists did not affect the social ability of mice. C Statistical analysis of interaction times between the test mouse and a novel mouse (Novel mouse, N) or a familiar mouse (Familiar mouse) (n = 6). Social novelty was disrupted in mice when oxytocin receptors were inhibited, while oxytocin did not affect social novelty in mice (n = 6). Data displayed as mean±S.E.M. *P < 0.05, ***P < 0.001, ****P < 0.0001.

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