Fig. 9: Automated MCAM analysis on genetic epilepsy models.
From: Automated detection of complex zebrafish seizure behavior at scale
a Total activity dot-plots are shown for six CRISPR-generated zebrafish congenic WT siblings and age-matched homozygote mutant lines: gabrb3 (101 WT, 74 mutant); pcdh19 (74 WT, 89 mutant); pnpo (94 WT, 184 mutant; unpaired t-test ****p < 0.0001); scn8aa (79 WT, 60 mutant); scn1lab (84 WT, 137 mutant; unpaired t-test ****p < 0.0001); syngap1b (45 WT, 133 mutant). b Ethogram plot for a representative scn1lab homozygote mutant zebrafish. The entire duration of the 5 min recording epoch for one representative larva is shown (top). Pie chart depicting percentage of each behavior performed at each recording epoch (bottom, left). Color coding as in Fig. 8. Scalar measurements plotted that align with ethogram showing various seizure-like behaviors (bottom, right).
