Fig. 8: Phylogenetic conservation of residue 134 of VP2 in nine hepatovirus species infecting different mammalian species. | Communications Biology

Fig. 8: Phylogenetic conservation of residue 134 of VP2 in nine hepatovirus species infecting different mammalian species.

From: The hepatocyte traffic network in the human hepatitis A virus biological cycle from an evolutionary perspective

Fig. 8: Phylogenetic conservation of residue 134 of VP2 in nine hepatovirus species infecting different mammalian species.

A scheme of the HAV genome is illustrated above the alignment. Position 134 of VP2 is indicated by a vertical black line. Residues are colored following the Mega color scheme (A in yellow, E and D in red, G in magenta, Y in light green, Q and S in green, and P in blue). The alignment was constructed using 132 sequences from the nine existing Hepatovirus species, plus an still unclassified virus, infecting 34 different mammalian species (A: Hepatovirus ahepa infecting apes and monkeys; B: Hepatovirus bephopi infecting seals; C: Hepatovirus cemanavi infecting bats; D: Hepatovirus devoli infecting rodents; E: Hepatovirus erubebrufu infecting rodents; F: Hepatovirus fejalco infecting rodents; G: Hepatovirus gafrisheta infecting bats; H: Hepatovirus hedgi infecting hedgehogs; I: Hepatovirus ishrewi infecting shrews and ?: an unclassified Hepatovirus infecting a marsupial) available at GenBank (EU526089, M20273.1, AY644676, AB279732, AB300205, M14707, HQ246217, KX088647, M59286, D00924, EU140838, KR703607, MG181943, KT452631-KT452747). The first seven sequences, belonging to hepatoviruses infecting humans and chimpanzees, show an S at position 134. The human HP strain represents an exception and aligns with sequences from monkeys and small mammals.

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