Fig. 2: Landscape of the tumor ecosystem in HBV positive and HBV negative HCC tumor tissues. | Communications Biology

Fig. 2: Landscape of the tumor ecosystem in HBV positive and HBV negative HCC tumor tissues.

From: Viral-Track integrated single-cell RNA-sequencing reveals HBV lymphotropism and immunosuppressive microenvironment in HBV-associated hepatocellular carcinoma

Fig. 2

A UMAP plot, showing the annotation for cluster number and colour codes for cell type in the HCC ecosystem. B The UMAP plot, showing patient IDs by colour (left panel); the bar graph represents patient cell counts (right panel). C UMAP plot, showing tumor type by colour, HBV(blue), or non-HBV HCC(green). D UMAP plot coloured by viral status, HBV-infected cells (green), and non-infected cells (red). E UMAP plot showing the expression levels of marker genes, defined for all cell types. F Scaled heatmap of marker gene expression in the indicated cell types. The top bars label cell-type clusters, and the number in brackets matches the cluster number in (A). G Histogram indicating the immune and non-immune cell fraction of each patient’s tumor tissue. H Pie chart of immune and non-immune cell subtypes in HBV and non-HBV-HCC tissues. See also Supplementary Figs. 3, 4, and 5.

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