Fig. 3: Neurobehavioral analyses of the ΔLYST-B6 mouse model. | Communications Biology

Fig. 3: Neurobehavioral analyses of the ΔLYST-B6 mouse model.

From: A murine model lacking Lyst recapitulates Chediak-Higashi syndrome with an earlier-onset neurodegenerative phenotype

Fig. 3

a Average cumulative composite ataxia scores from ataxia screening of WT and ΔLYST-B6 mice from the age of 6 to 18 months. 6 mo: n = 18 ΔLYST-B6 (7 male, 11 female), n = 17 WT (9 male, 8 female); 7 mo: n = 18 ΔLYST-B6 (7 male, 11 female), n = 17 WT (9 male, 8 female); 8 mo: n = 17 ΔLYST-B6 (6 male, 11 female), n = 16 WT (9 male, 7 female); 9 mo: n = 26 ΔLYST-B6 (9 male, 17 female), n = 18 WT (5 male, 13 female); 10 mo: n = 11 ΔLYST-B6 (female only), n = 7 WT (female only); 11 mo: n = 17 ΔLYST-B6 (6 male, 11 female), n = 16 WT (9 male, 7 female); 12 mo: n = 31 ΔLYST-B6 (11 male, 20 female), n = 31 WT (17 male, 14 female), Heterozygous n = 3 (1 male, 2 female); 13-15 mo: n = 6 ΔLYST-B6 (male only), n = 9 WT (male only); 18 mo: n = 7 ΔLYST-B6 (3 male, 4 female), n = 7 WT (female only). b Average descent times from the inverted pole test of WT and ΔLYST-B6 mice from the age of 6 to 18 months. 6 mo: n = 18 ΔLYST-B6 (7 male, 11 female), n = 19 WT (9 male, 10 female); 7 mo: n = 18 ΔLYST-B6 (7 male, 11 female), n = 19 WT (9 male, 810 female); 8 mo: n = 17 ΔLYST-B6 (6 male, 11 female), n = 19 WT (9 male, 10 female); 9 mo: n = 14 ΔLYST-B6 (9 male, 5 female), n = 11 WT (5 male, 6 female); 10 mo: n = 17 ΔLYST-B6 (6 male, 11 female), n = 19 WT (9 male, 10 female); 11 mo: n = 17 ΔLYST-B6 (6 male, 11 female), n = 18 WT (9 male, 9 female); 12 mo: n = 31 ΔLYST-B6 (11 male, 20 female), n = 32 WT (17 male, 15 female), n = 3 Heterozygous (1 male, 2 female); 13 mo: n = 6 ΔLYST-B6 (male only), n = 9 WT (male only); 14-15 mo: n = 4 ΔLYST-B6 (male only), n = 9 WT (male only); 18 mo: n = 7 ΔLYST-B6 (3 male, 4 female), n = 7 WT (female only). c Average cross time of 24-mm beam and 12-mm beam from the horizontal balance beam test of WT and ΔLYST-B6 mice from the age of 6 to 18 months. 6 mo: n = 18 ΔLYST-B6 (7 male, 11 female), n = 18 WT (9 male, 9 female); 7 mo: n = 18 ΔLYST-B6 (7 male, 11 female), n = 18 WT (9 male, 9 female); 8 mo: n = 18 ΔLYST-B6 (7 male, 11 female), n = 18 WT (9 male, 9 female); 9 mo: n = 25 ΔLYST-B6 (9 male, 16 female), n = 29 WT (14 male, 15 female); 10 mo: n = 17 ΔLYST-B6 (6 male, 11 female), n = 17 WT (9 male, 8 female); 11 mo: n = 17 ΔLYST-B6 (6 male, 11 female), n = 17 WT (9 male, 8 female); 12 mo: n = 31 ΔLYST-B6 (11 male, 20 female), n = 31 WT (17 male, 14 female), n = 3 Heterozygous (1 male, 2 female); 13-15 mo: n = 6 ΔLYST-B6 (male only), n = 9 WT (male only); 18 mo: n = 7 ΔLYST-B6 (3 male, 4 female), n = 7 WT (female only). Inkblot gait analysis measurements (d) and average stride length, stance width, and paw angle (e) from inkblot gait analysis of WT and ΔLYST-B6 mice at the age of 12 months. n = 10 ΔLYST-B6 (3 male, 7 female), n = 4 WT (2 male, 2, female). Student’s two-sample t-test: *P < 0.05, **P < 0.01, ***P < 0.001. WT, wild-type; ΔLYST-B6, Lyst homozygous knockout (C57BL/6 J background).

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