Table 5 Top 5 enriched pathways from RNA-seq analysis of the forebrain and cerebellum in 3*- and 18-month-old WT and ΔLYST-B6 mice
Brain Region | Age (Months) | GOBP Term | Description | Enrichment Ratio | FDR |
|---|---|---|---|---|---|
Forebrain | 3 | GO:0046683 | response to organophosphorus | 15.0 | 4.19E−5 |
Forebrain | 3 | GO:0014074 | response to purine-containing compound | 13.2 | 5.66E−5 |
Forebrain | 3 | GO:0042326 | negative regulation of phosphorylation | 5.15 | 1.44E−2 |
Forebrain | 3 | GO:1901652 | response to peptide | 4.76 | 1.96E−2 |
Forebrain | 3 | GO:0009612 | response to mechanical stimulus | 7.09 | 3.11E−2 |
Forebrain | 18 | GO:0072376 | protein activation cascade | 33.1 | 1.89E−5 |
Forebrain | 18 | GO:0002443 | leukocyte mediated immunity | 9.60 | 2.29E−5 |
Forebrain | 18 | GO:0002250 | adaptive immune response | 7.50 | 6.03E−4 |
Forebrain | 18 | GO:0019882 | antigen processing and presentation | 18.2 | 1.53E−3 |
Forebrain | 18 | GO:0002253 | activation of immune response | 7.20 | 1.79E−3 |
Cerebellum | 18 | GO:0002443 | leukocyte mediated immunity | 7.23 | 9.02E−14 |
Cerebellum | 18 | GO:0006909 | phagocytosis | 10.1 | 1.07E−11 |
Cerebellum | 18 | GO:0002250 | adaptive immune response | 6.06 | 1.07E−11 |
Cerebellum | 18 | GO:0042110 | T cell activation | 5.06 | 1.59E−9 |
Cerebellum | 18 | GO:0002697 | regulation of immune effector process | 5.50 | 4.45E−9 |
