Fig. 5: Superpositions of the double mutant inhibitor complexes on the corresponding MProWT complexes. | Communications Biology

Fig. 5: Superpositions of the double mutant inhibitor complexes on the corresponding MProWT complexes.

From: Characterization of an unusual SARS-CoV-2 main protease natural variant exhibiting resistance to nirmatrelvir and ensitrelvir

Fig. 5: Superpositions of the double mutant inhibitor complexes on the corresponding MProWT complexes.

A MProD48Y/ΔP168-GC373 aligned with MProWT-GC373 (PDB ID 7UKK). B MProD48Y/ΔP168-NMV aligned with MProWT-NMV (PDB ID 7SI9). C MProD48Y/ΔP168-PMV aligned with MProWT-PMV (PDB ID 8TBE). D Superimposition of the MProD48Y/ΔP168-ESV and MProWT-ESV complexes. Double mutant carbon atoms are colored yellow and green and cartoon in blue; the MProWT carbon atoms are purple with a cartoon model in light purple. All distances are in Angstrom.

Back to article page