Fig. 3: Cortical density differences between neuroreceptor modules.

A The average density of the neuroreceptors and transporters part of the NR1 module. Module density map was estimated by averaging the z-score normalized neuroreceptor and transporter density maps part of the NR1 module. See Fig. S1 for individual neuroreceptor and transporter density maps. B Same as panel A, but for the NR2 module. C Difference in the density across the cortex between the NR1 and NR2 modules. NR2-associated neuroreceptors and transporters exhibited greater density in the frontal, motor, and visual cortices, while the NR1 module was more prominent in the orbitofrontal, parietal, and temporal regions. D Density differences between NR1 and NR2 modules among large-scale brain networks. Statistical significance was based on an independent samples t-test and Bonferroni corrected for multiple comparisons. Error bars show mean ± sem. E and F Pearson correlation between spatial density differences, panel C, and 100 cognitive terms in Neurosynth. Only terms with significant (P < 0.05 FDR corrected) correlations are shown. FPN frontal parietal network, DMN default mode network, DAN dorsal attention network, LIM limbic network, VAN ventral attention network, SOM somatomotor network, VIS visual network. ***P < 0.001.