Table 2 Ancestry-enriched pharmacogenomic variant associations

Gene	Chr.	Position	rsID^a	Pharmacogenomic Effect^b	Evidence level^c	Allele count^d	Fisher’s P-value^e	F_ST^f	Ancestry enrichment^g
CYP3A4	7	99767460	rs4646437	Tacrolimus metabolism	2A	2406	1.28E−82	0.194	AFR
KIF6	6	39357302	rs20455	Pravastatin metabolism	2B	1058	6.83E−33	0.139	AFR
CHRNA5	15	78590583	rs16969968	Nicotine dependence	2B	2544	8.82E−21	0.035	EUR
VKORC1	16	31093557	rs9934438	Warfarin metabolism	1B	2552	1.69E−18	0.032	AME
MTHFR	1	11796321	rs1801133	Methotrexate toxicity	2A	2574	2.18E−18	0.032	AME
CYP4F2	19	15879621	rs2108622	Warfarin metabolism	1A	2628	1.34E−13	0.023	EUR
VKORC1	16	31092475	rs2359612	Warfarin metabolism	1B	2428	1.66E−13	0.026	AFR
XRCC1	19	43551574	rs25487	Platinum-based medication metabolism	2B	1326	1.60E−12	0.041	AFR
VKORC1	16	31096368	rs9923231	Warfarin metabolism	1A	1918	4.69E−11	0.024	EUR
CYP2B6	19	41012316	rs28399499	Antiretroviral metabolism	2A	2512	2.37E−10	0.028	AFR
MSRB1P1	19	39252525	rs8099917	PEG-IFN alpha metabolism	1B	1762	3.14E−10	0.025	ADX1
SLCO1B1	12	21178615	rs4149056	Simvastatin toxicity	1A	2512	4.91E−08	0.013	EUR

^aSingle nucleotide polymorphism (SNP) identifier from the NCBI dbSNP database.
^bDrug and effect mode for each pharmacogenomic association.
^cPharmGKB database evidence level.
^dTotal number of alleles used for Fisher’s exact test.
^eP-value for 2 × 5 Fisher’s exact test; 2 allele types (reference & alternate) Χ 5 ancestry clusters.
^fFixation index (F_ST) across the five ancestry clusters.
^gAncestry cluster that shows the highest alternate allele frequency.

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