Fig. 4: Pan-cancer analysis of the mutations attributed to spontaneous deamination. | Communications Biology

Fig. 4: Pan-cancer analysis of the mutations attributed to spontaneous deamination.

From: CG>TG mutation frequency as negative predictor of homologous recombination deficiency in ovarian and breast cancer

Fig. 4: Pan-cancer analysis of the mutations attributed to spontaneous deamination.

Analysis of the fraction of C > T transition at CpG sites relative to all SBSs (fdeam). A Level of fdeam across cancer types. Cancer types were stratified into “low fdeam“ and “high fdeam“ based on the percentage of tumors below and the above the cutpoint 13.1% for fdeam. B Performance of fdeam was non-inferior to HRDsum for the detection of HRD in 17 cancer types including ovarian and breast cancer. C, D Performance of fdeam was non-inferior to HRDsum for the detection of HRD in a pooled data set of entities with high fdeam (n = 14), but inferior to HRDsum in a pooled data set of entities with low fdeam (n = 17). TCGA-PANCAN* = all entities included in the TCGA except BRCA and OV.

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