Fig. 5: HRD detection in tumors of low tumor purity. | Communications Biology

Fig. 5: HRD detection in tumors of low tumor purity.

From: CG>TG mutation frequency as negative predictor of homologous recombination deficiency in ovarian and breast cancer

Fig. 5: HRD detection in tumors of low tumor purity.

Starting from a cohort of 40 ovarian carcinoma with tumor purity ≥80%, corresponding cohorts with homogenous tumor purity of 60%, 40%, 20%, 10%, and 5% were simulated. A ROC analysis of the performance of fdeam and HRDsum. B Accuracy for the detection of HRD with fdeam (cutpoint: 13.1%) and with HRDsum (cutpoint: 42).

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