Fig. 1: Structure of the D2HDH/NADP+/2-ketohexanoic acid complex (pdb:9ibe). | Communications Biology

Fig. 1: Structure of the D2HDH/NADP+/2-ketohexanoic acid complex (pdb:9ibe).

From: Potassium binding by carbonyl clusters, halophilic adaptation and catalysis of Haloferax mediterranei D-2-hydroxyacid dehydrogenase

Fig. 1: Structure of the D2HDH/NADP+/2-ketohexanoic acid complex (pdb:9ibe).

a A cartoon of the D2HDH dimer (beige and teal) viewed down the molecular 2-fold with the NADP+ (green carbons) and 2-ketohexanoic acid (yellow carbons) in ball and stick format. b Monomers of the D2HDH apo enzyme (blue) and the NADP+/2-ketohexanoic acid complex (beige) overlapped on their d2 domains, showing domain closure on substrate binding. c The active site of D2HDH (beige carbons and transparent surface) showing the NADP+ (green carbons) and 2-ketohexanoic acid (yellow carbons), with hydrogen bonds shown as black dashes and with the NADP+ nicotinamide ring C4, the C2 of the substrate and interacting residues labelled. d The conversion of a 2-ketoacid to a D-2-hydroxyacid, the reaction catalysed by D2HDH.

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