Fig. 7: Pol IV-mutational signatures on the P. aeruginosa genome from clinical isolates.
From: The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa
A SNP density plots for the genome of 411 clinical, 59 Cystic Fibrosis (CF) and 58 environmental isolates. The SNP density at each 0.25 Mbp bin was calculated as the total number of SNPs in the bin divided by the number of genomes. Total SNP, transition and transversion densities were plotted as a function of distance from the origin of replication. The dotted line indicates the overall density of SNPs for the chromosome. The Iglewicz and Hoaglin’s robust test for multiple outliers (two sided test) was used to detect outlier SNP densities in the genome. Asterisks denote a significant outlier SNP density among genome regions. B–E AT>CG mutations in the pyoverdine pathway from clinical isolates. The proportion of mutated trinucleotides (B) and codons (C); and the proportion of the target (D) and final (E) amino acids among mutations found in the pyoverdine genes are shown.
