Table 2 Description of all GWAS summary-level data

From: Unveiling causal relationship between white matter tracts and psychiatric disorders

	Source	Parameters	Number of tracts	Number of DTI traits	Sample (total)	Pubmed ID
GWAS summary-level data of white matter tracts
White matter tracts	Zhao et al.³⁶	AD, FA, MD, MO, RD	21	110	33,292	34140357
GWAS summary-level data of psychiatric disorders (Bidirectional MR)
Disease	Source	Sample (cases)	Sample (control)	Sample (total)	Ancestry	Pubmed ID
Alcohol use disorder		113,325	639,923	753,248	EUR	38062264
	iPSYCH	3141	18,970	22,111	EUR
	MVP	80,028	368,113	448,141	EUR
	UKB	-	-	-	EUR
	FinnGen	8866	209,926	218,792	EUR
	QIMR	10,785	10,848	21,633	EUR
	PGC	9938	30,992	40,930	EUR
	Yale-Penn 3	567	1074	1641	EUR
Attention deficit hyperactivity disorder		38,691	186,843	225,534	EUR	36702997
	iPSYCH	-	-	-	EUR
	deCODE	-	-	-	EUR
	PGC	-	-	-	EUR
Autism disorder		18,381	27,969	46,350	EUR	30804558
	iPSYCH	13,076	22,664	35,740	EUR
	PGC	5305	5305	10,610	EUR
	FinnGen	-	-	-	EUR
Bipolar disorder	PGC	41,917	371,549	413,466	EUR	34002096
Cannabis use disorder		42,281	843,744	886,025	EUR	37985822
	PGC, deCODE	14,522	298,941	313,463	EUR
	MVP	22,260	423,587	445,847	EUR
	iPSYCH	4733	95,657	100,390	EUR
	MGB	456	24,088	24,544	EUR
	Yale-Penn 3	310	1471	1781	EUR
Major depression		184,270	529,044	713,314	EUR	37464041
	iPSYCH	29,158	38,142	67,300	EUR
	FinnGen	28,098	228,817	256,915	EUR
	MVP	83,810	166,405	250,215	EUR
	PGC	43,204	95,680	138,884	EUR
Opioid Use Disorder	MVP, PGC, iPSYCH, FinnGen, Partners Biobank, BioVU, and Yale-Penn 3	15,251	554,186	569,437	EUR	35879402
Post-traumatic stress disorder	PGC	137,136	1,085,746	1,222,882	EUR	38637617
Schizophrenia	PGC	52,017	75,889	127,906	EUR	35396580
Tourette syndrome	PGC	4819	9488	14,307	EUR	30818990
GWAS summary-level data of psychiatric disorders (Replication)
Disease	Source	Sample (cases)	Sample (control)	Sample (total)	Ancestry	Pubmed ID
Alcohol use disorder	FinnGen	18,695	435,038	453,733	EUR	-
Attention deficit hyperactivity disorder	FinnGen	3702	445,327	449,029	EUR	-
Bipolar disorder	FinnGen	8209	394,756	402,965	EUR	-
Schizophrenia	FinnGen	6933	439,144	446,077	EUR	-

All download links were in Supplementary Data 2.
AD Axial diffusivities, deCODE deCODE Genetics, DTI Diffusion tensor imaging, EUR European, FA Fractional anisotropy, iPSYCH The Lundbeck Foundation Integrative Psychiatric Research, MD Mean diffusivities, MGB Mass General Brigham Biobank, MVP the Million Veteran Program, MO Mode of anisotropy, PGC Psychiatric Genomics Consortium, QIMR QIMR Berghofer Medical Research Institute, RD Radial diuffsivities, UKB UK Biobank.

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Table 2 Description of all GWAS summary-level data

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