Fig. 1: Analytic strategy to derive polygenic scores related to insulin resistance in TOPMed. | Communications Biology

Fig. 1: Analytic strategy to derive polygenic scores related to insulin resistance in TOPMed.

From: Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program

Fig. 1: Analytic strategy to derive polygenic scores related to insulin resistance in TOPMed.The alternative text for this image may have been generated using AI.

LD Linkage Disequilibrium, T2D Type 2 Diabetes, FI Fasting Insulin, MtS Metabolic Syndrome, ALP alkaline phosphatase. EUR/AFR/AMR denotes LD reference panels provided by PRS-CSx and constructed using the UK Biobank data (Pan UKBB European ancestry, African ancestry, and Admixed American ancestry); Left-side panel has been adapted from Ruan et al.68.

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