Table 4 Association results of the metabolic syndrome van Walree European GWAS polygenic score (n = 318 genetic variants) [PMID: 35983957] with neurological outcomes in TOPMed

From: Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program

 

Effect estimates in the pooled sample

B

SE

P

Dementia

0.157

0.168

0.35

Alzheimer’s disease

0.087

0.188

0.64

General Cognitive Function

−0.104

0.030

0.0004

General Cognitive Function, excluding participants with prevalent diabetes at the time of neurological traits measurement

−0.109

0.031

0.0005

General Cognitive Function in APOE-ε4 non-carriers

−0.151

0.039

8.7 × 10−5

Hippocampal Volume

−0.047

0.038

0.22

Total Brain Volume

−2.613

1.984

0.19

Lateral Ventricular Volume

0.063

0.023

0.005

Total Cranial Volume

−1.010

6.218

0.87

  1. Threshold for significance: P = 0.05/9 = 0.006.
  2. P-values in bold and italics are significant after multiple-testing correction.
  3. N Dementia and Alzheimer’s disease analyses: 9388; N General Cognitive Function analyses: 19,191; N volumes derived from MRI: 7674.
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