Fig. 1: Positive enrichment of T cells and negative enrichment of macrophages in Emphysematous COPD (E-COPD).
From: Lung NR3C1+ and CXCR6high T cells distinguish immunopathogenesis of human emphysema
a Study design for in-house discovery dataset (b–f), and (g) for validation dataset (h–j). UMAP embedding of the global cellular landscape for the in-house discovery dataset (b) and the published validation dataset (h). Collective cellular proportions across disease groups in the in-house discovery dataset (c) and published validation dataset (i). Pairwise comparison of cell type differential abundance using scCODA in in-house discovery dataset between E-COPD vs. Control (d), E-COPD vs. NE-COPD (e), and NE-COPD vs Control (f). Pairwise comparison of cell type differential abundance using scCODA in the published validation dataset between COPD and Control (j). The final parameter shown on the horizontal axis indicates degrees of enrichment. Positive values suggest positive enrichments, and negative values suggest negative enrichments. The false discovery rate (FDR) for scCODA differential abundance analyses was set at a threshold of 0.25. Artwork was generated from Bioicons (https://bioicons.com/) and NIH NIAID BioArt Source (https://bioart.niaid.nih.gov/). Modifications of the artwork were performed in Inkscape (https://inkscape.org/).
