Fig. 2: Unique transcriptional signatures of CD4 T cells in Emphysematous COPD (E-COPD).
From: Lung NR3C1+ and CXCR6high T cells distinguish immunopathogenesis of human emphysema
a Transcription factor activity estimation with a univariate linear model of CD4 T cells using decoupleR in Controls, Nonemphysematous COPD (NE-COPD), and Emphysematous COPD (E-COPD) in the in-house discovery dataset. b Functional enrichment of biological terms by over-representation analyses (ORA) of CD4 T cells across Controls, NE-COPD, and E-COPD using Hallmark pathway gene set in the in-house discovery dataset. Gene set variation analyses (GSVA) of Leukocyte response to cytokine (Gene Ontology) (c), Leukocyte response to chemokine (Gene Ontology) (d), IL2 mediated signaling (KEGG) (e), and IL6-JAK-STAT3 Signaling (KEGG) (f) and IL17 production (g) across three disease groups in the in-house discovery dataset. Statistical significance between the 3 groups was determined using the Kruskal–Wallis’ test. Pairwise comparisons were performed using Wilcoxon rank-sum test with Holm’s correction. Significance code: p < 0.05(*), p < 0.01(**), p < 0.001 (***), ns: non-significant.
