Fig. 7: CXCR6High effector CD4 positively correlates with %FEV1 in E-COPD.
From: Lung NR3C1+ and CXCR6high T cells distinguish immunopathogenesis of human emphysema
a UMAP embedding of CD4 effector memory subsets in the in-house discovery dataset. b Violin plot of CXCR6 expression in CD4 effector memory subsets. c Heatmaps of gene signature expression and (d) decoupleR estimation of transcriptional factor activities in CXCR6High and CXCR6Low CD4 effector memory subsets. e UMAP embedding of CytoTRACE pseudotime in CD4 effector memory. f Cellrank estimation of differentiation trajectory in CD4 effector memory subsets. Higher values of cytoTRACE pseudotime indicate a higher level of differentiation. g Driver genes for CXCR6Low CD4 effector memory differentiation from CXCR6High CD4 effector memory. Expressions of driver genes (y-axis) were plotted against CytoTRACE pseudotime (x-axis), the shadow of the curve denotes 95% confidence intervals. h Spearman correlation of CXCR6High CD4 effector memory percentages in CD4 and %FEV1 in 3 disease groups.
