Fig. 1: Visual food cue stimulation induces an increase in α4β2* nicotinic acetylcholine receptor availability in individuals with obesity and disinhibited eating behavior.
From: Cholinergic network modulation in disinhibited eating behavior
a Visual food cue paradigm during scan compared with resting state examination (see also Methods) b Volumes of distribution (VT) in all study participants of the three groups indicating significantly lower VT (p < 0.05) participants with obesity compared with normal-weight controls regardless whether they were at resting state or under stimulation. The presentation of food cues itself led to significant between-subject effects with elevated VT in the thalamus in individuals with obesity and high disinhibited eating behavior (p < 0.05). c Representative parametric images of VT scaled to the same maximum indicating an increase of VT in one individual with obesity under visual food-cue stimulation as compared with one normal-weight healthy control. For individuals VT changes between rest and stimulus see Supplementary Fig. 2. d Parametric images of averaged VT changes of the observed differences between rest and stimulus for normal-weight healthy controls, individuals with obesity with low and high disinhibited eating behavior (stereo-tactically normalized into MNI space). Compared to rest condition, blue colors indicate a decrease and red colors an increase at stimulus condition.
