Table 1 Noteworthy cis-pQTL associations with colocalising Mendelian randomisation outcomes

From: Efficient candidate drug target discovery through proteogenomics in a Scottish cohort

cis-pQTL

Gene

Colocalising MR outcome

Coloc PP.H4

GWAS-log(p)

GWAS effect size

MR-log(p)

MR effect size

rs78760579

B3GAT1

Prostate cancer

0.91

7.4

−0.80

6.7

−0.080

rs1473781

LTK

Type 2 diabetes

0.95

12.1

0.69

5.2

0.054

rs10931931

NIF3L1

Early age-related macular degeneration

0.81

11.2

0.88

5.7

−0.11

rs13258747

NTAQ1

Total testosterone

0.88

10.8

−0.62

5.5

−0.02

rs72941336

AAMDC

Intrinsic epigenetic age acceleration

0.90

14.6

−0.99

5.0

0.22

rs1169084

BCL7A

Systolic blood pressure

0.85

9.7

0.68

5.5

0.23

rs56953556

COMMD10

Parental longevity (mother’s attained age)

0.90

11.1

−1.34

5.4

−0.016

  1. The table showcases causal associations identified in this study between pQTL, protein levels and diseases or health outcomes that may be of medical interest. pQTL protein Quantitative Trait Locus, MR Mendelian randomisation, Coloc PP.H4 posterior probability of colocalisation. Proteins represented: B3GAT1 Beta-1,3-Glucuronyltransferase 1, LTK leukocyte receptor tyrosine kinase, NIF3L1 NGG1 interacting factor 3 like 1, NTAQ1 N-Terminal Glutamine Amidase 1, AAMDC Adipogenesis Associated Mth938 Domain Containing protein, BCL7A BAF Chromatin Remodelling Complex Subunit BCL7A, COMMD10 COMM Domain-Containing Protein 10.
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