Fig. 5: ODBAE identifies new metabolic genes from a metabolism-related dataset of knockout mice.

a The proportion of important genes identified in the male and female datasets. b ODBAE identified 128 important genes in the male dataset and 111 important genes in the female dataset, for a total of 203 important genes. c Sexually dimorphic genes identified by ODBAE, with previously reported sexually dimorphic genes highlighted in red. d Visualization results of outliers corresponding to gene Crabp1 in the subspace formed by abnormal parameters. The absolute z-score values of Alb or HDLC of the data points in the shaded part are ranked in the top 1.2%. e Validation results of important genes in the MGI database. 78.8% of the genes are associated with metabolism, and 21.2% are newly identified by ODBAE. Besides, 51.2% and 44.2% new metabolic genes are identified in the male or female datasets, respectively, and 4.7% are detected in both male and female datasets. f Histogram of KEGG pathway enrichment for 43 novel genes in mice obtained through KOBAS.