Fig. 7: Validation of the top three abnormal parameter pairs that occur in both males and females and have the highest overall frequency. | Communications Biology

Fig. 7: Validation of the top three abnormal parameter pairs that occur in both males and females and have the highest overall frequency.

From: ODBAE: a high-performance model identifying complex phenotypes in high-dimensional biological datasets

Fig. 7

a Visualization of outliers corresponding to gene Lepr based on abnormal parameter pairs in the male dataset. b The distribution of the standardized ratio of ALA to HDLC in mouse metabolism-related dataset, the average ratio of Lepr knockout mice is significantly smaller. c Histogram of KEGG pathway enrichment for genes corresponding to (ALA, HDLC) in humans. d Visualization of outliers corresponding to gene Ap4m1 based on abnormal parameter pairs in the female dataset. e The distribution of the standardized ratio of ASA to Alb in mouse metabolism-related dataset, the average ratio of Ap4m1 knockout mice is significantly larger. f Histogram of KEGG pathway enrichment for genes corresponding to (Alb, ASA) in humans.

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