Fig. 1: Metabolic pattern and characteristics of main organs during late gestation.
From: Metabolomic landscape of fetal organ development during late gestation in mice
a The workflow of this study (created with Biorender). b The metabolic pattern of organs by using PLS-DA analysis. Various scattered icons represent different tissue samples, and colors represent different developmental times. c Heatmap showing the identified 136 metabolites in 5 organs at E15.5, E16.5, E18.5, E19.5, with color indicating the expression level of the metabolites, red indicating higher expression level, and blue indicating lower expression level. d The log10(abundance) of energy related metabolites in 5 organs at E15.5, E16.5, E18.5 E19.5. e The log10(abundance) of 4-pyridoxic acid in 5 organs at E15.5, E16.5, E18.5 E19.5. The significance was analyzed by Student’s t-test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). The sample sizes were: n = 5 (heart and stomach at E15.5), n = 7 (heart at E16.5), and n = 6 (all other groups). Error bars represent mean ± SD.
