Fig. 2: Crystal structure of 1122A11 Fab in complex with Singapore16 N2 NA at 2.2 Å resolution. | Communications Biology

Fig. 2: Crystal structure of 1122A11 Fab in complex with Singapore16 N2 NA at 2.2 Å resolution.

From: Structure and function of a cross-neutralizing influenza neuraminidase antibody that accommodates recent N2 NA Asn245 glycosylation

Fig. 2

a The NA tetramer with one Fab bound to each NA protomer. b An NA protomer bound to one Fab. c The antibody epitope residues on the NA. d The antibody paratope residues superimposed on the NA surface in a similar view to panel (c). For all panels, one NA-Fab protomer is colored with NA in light gray, and Fab light chain in yellow, Fab heavy chain in orange, and the NA and Fab in other NA protomers are in dark and light gray, respectively. N-linked glycans in (b) are represented in sticks with yellow carbon atoms. A bound calcium ion in (b) is shown as a green sphere. The epitope residues labeled in pink in (c) are conserved residues in influenza A N1-N9 and influenza B NA subtypes. The molecular surface depicting the epitope in (d) is colored in green.

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