Fig. 3: The conformational flexibility of Derlin-1.
From: Cryo-EM structure of the human Derlin-1/p97 complex reveals a hexameric channel in ERAD
a Structural comparison of Derlin-1 protomers in different states. The structural models of Derlin-1 protomers from the hexameric channel (red), the tetrameric channel (4:6 complex state A, yellow), and the “U”-shaped tetrameric states (4:6 complex state U, blue) are displayed as cartoon models and viewed from three distinct angles to illustrate their conformational flexibility. b Central tunnel architecture of tetrameric and hexameric Derlin-1 channels. The central tunnels formed by the tetrameric Derlin-1 channel (left, 4:6 complex state A) and the hexameric Derlin-1 channel (right, 6:6 complex) are shown as electrostatic surface potential maps. The P66 residues, which define the narrowest point of the tunnel, are rendered as transparent to highlight the channel pathways.
