Fig. 4: The NTD of p97 in different states.
From: Cryo-EM structure of the human Derlin-1/p97 complex reveals a hexameric channel in ERAD
a Comparison of p97NTD in different conformations. The p97 protomers from the p97-ADP complex, p97-ATPγS complex, Der-p97 6:6 complex, and Der-p97 4:6 complex in state A and U were structurally aligned using the D1-D2 domain as reference. Their NTDs were shown as surface model and colored in red (for protomers A/C/E from 6:6 complex), pink (for protomers B/D/F from 6:6 complex), light yellow (for protomer C from 4:6 complex, state A), dark yellow (for protomer D from 4:6 complex, state A), light green (for p97-ADP complex), dark green (for p97-ATPγS complex), and blue (for 4:6 complex, state U). The surface models of p97NTD were sliced for a clear observation of their lifting angles. b The cartoon representations of the p97 NTD conformations in (a). c The p97 protomers in different complexes.
