Fig. 5: A schematic diagram illustrating the proposed transitions.
From: Cryo-EM structure of the human Derlin-1/p97 complex reveals a hexameric channel in ERAD
During ERAD, p97 associates with Derlin-1 tetramers to form a 4:6 complex, which can adopt either a closed (state A) or a side-open (state U) conformation. Depending on substrate size and nucleotide state, the complex either accommodates small substrates directly or recruits an additional Derlin-1 dimer to form the 6:6 assembly, thereby enabling retrotranslocation of larger substrates.
