Fig. 1: The S. aureus MecA/ClpC/ClpP protease complex.
From: Structure of the central Staphylococcus aureus AAA+ protease MecA/ClpC/ClpP
a Consensus cryo-EM map of the complex showing the different protein components and the local resolution. b Composite map obtained by combining the map of the MecA crown with the map of the ClpC/ClpP body using Phenix. MecA is colored in gold, ClpC subunits in shades of red and ClpP protomers in shades of blue-gray. c Refined map of the MecA crown, which includes the ClpC N-terminal domain (NTDs) and the coil-coiled M-domain (MDs). C6 symmetry was applied. d Refined map of the ClpC/ClpP body, which includes the hexamer of ClpC and the tetradecameric ClpP chamber. e Refined and D7 symmetrised map of the tetradecameric ClpP chamber.
