Fig. 9: Distant Fos elevations: recruitment of mesocorticolimbic circuitry during maladaptive attraction to shock rod.

a Diagram shows distant brain structures in which Fos elevations were recruited in hSyn ChR2 rats (N = 10; orange) or D1 ChR2 rats (N = 10; blue) during shock rod attraction. b Shows quantitative levels of Fos expression in D1 ChR2 and hSyn ChR2 rats immediately after shock rod attraction, as well as in eYFP control rats and naïve unoperated control rats. Structures include: prelimbic cortex (PL), infralimbic cortex (IL), medial shell of nucleus accumbens (NAcsh), core of nucleus accumbens (NAcc), dorsomedial neostriatum (DMS), medial amygdala (MeA), lateral hypothalamus (LH), and ventral tegmentum (VTA). Data represent means and SEM. **p < 0.01, ***p < 0.001.