Fig. 6: Identification of putative differences in cell-specific transcription factors between Tau and WT rats at 10 months of age. | Communications Biology

Fig. 6: Identification of putative differences in cell-specific transcription factors between Tau and WT rats at 10 months of age.

From: Intercellular signaling and synaptic deconstruction uncovered by single-cell and spatial transcriptomics in an AD tauopathy model

Fig. 6

a Enrichment of the indicated TF motifs in astrocytes, microglia, oligodendrocytes and OPC. The size of each point represents the percentage of cells expressing this motif and the color of each point represents the motif enrichment P-value (–log10 P-value). b Transcription factor binding site (TFBS) motifs for selected TF in each cell type are shown and associated ridge plots showing distributions of the Z-score of motif deviation scores in Tau and control rats. c TF motifs enrichment in DG Glut, CA1-ProS Glut, CA3 Glut, CT/NP SUB Glut, Sst/Pvalb Gaba neurons. d TFBS motifs of selected TF for specific cell types.

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