Fig. 3: Genes expressed at mid-gestation in cortical regions with high network degree at birth are associated with the development of cortical circuitry.
From: Transcriptomic divergence of network hubs in the prenatal human brain
A Number of significant associations (pFDR < 0.05) between regional estimates of network degree at term-equivalent age and gene expression in mid-gestation in each of five developmental tissue zones. B Individual positive (top) and negative (bottom) associations with node degree for each gene (n = 7485 in each zone). The top 10 strongest associations are annotated in each row. C Mean node degree of each region in the µBrain cortical atlas. D Average (log-normalised) expression of four genes with positive (hub\(+\), left) and negative (hub\(-\), right) associations with node degree, displayed on the cortical surface. Scatterplots illustrate associations between degree and average gene expression, averaged over all brain specimens. E Gene ontology (GO) enrichments (FDR-corrected) for biological processes in hub\(+\) genes.
