Fig. 3: Molecular characterization of plasma cell spatial heterogeneity. | Communications Biology

Fig. 3: Molecular characterization of plasma cell spatial heterogeneity.

From: Characterization of the bone marrow architecture of multiple myeloma using spatial transcriptomics

Fig. 3: Molecular characterization of plasma cell spatial heterogeneity.The alternative text for this image may have been generated using AI.

a Spatial gene expression of pathological PC canonical markers. b Anatomical position of the identified areas (Remote zone, Border zone and Hotspot) based on their malignant PC signature. c Spatial distribution of the twelve identified MM-PC groups (Pg1-Pg12). d Heatmap of the top 1% most highly variable genes between the Pg groups shown in (c). e Violin plots of selected genes from (d). f Selected Gene Ontology (GO) terms derived from the over-representation analysis (ORA) of the most variable genes identified in (d) across Pg groups (the entire list is in Supplementary Data 2). Scales of 500 μm (a and b).

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