Fig. 4: Spatial identification of transcriptional programs associated with multiple myeloma pathogenesis.
From: Characterization of the bone marrow architecture of multiple myeloma using spatial transcriptomics
a Spatial distribution of the T cell effector (upper panels) and T cell exhaustion (bottom panels) scores in the pathological samples. b Box plots illustrating the T cell effector and T cell exhaustion scores across different identified areas, with their corresponding p-values. c Correlation between the T cell effector and T cell exhaustion profiles in the three identified areas. d Venn diagram displaying the differentially expressed genes (DEG) between the different areas (Remote zone, Border zone, and Hotspot). e Bar plot indicating upregulated KEGG pathways from the 231 commonly upregulated genes identified in (d). f Box plots of selected KEGG pathways from (e). g Spatial distribution and h violin plots of Padi4, Pik3cd, and Mmp9 genes expression level. Scales of 500 μm (a and g).
