Fig. 5: Investigation of Miro2 and CISD1 involvement on mitochondria. | Communications Biology

Fig. 5: Investigation of Miro2 and CISD1 involvement on mitochondria.

From: Proximity labeling unveils potential roles of the Miro2-CISD1 network in mitochondrial dynamics and neuronal differentiation

Fig. 5

a Representative transmission electron microscopy images acquired after transfection of siMiro2 and/or siCISD1. Scale bar: 1 μm. b Reconstructed images of TMRM-stained mitochondria following Miro2 and/or CISD1 knockdown, processed using the Imaris program. Scale bar: 10 μm. c Quantification of aspect ratio (M/m) after Miro2 and CISD1 siRNA treatment. “M” and “m” represent the major and minor axes of mitochondria, respectively. Created in BioRender. Woo, H. (2025) https://BioRender.com/ije8ur1. d Quantification of the distance from the nucleus to the mitochondria after Miro2 and CISD1 siRNA treatment. “D” represents the distance from the nucleus to the mitochondria. Created in BioRender. Woo, H. (2025) https://BioRender.com/nygjckv. n = 3, 15 mitochondria per cell, biologically independent experiments. ***p = 0.0000. The data in the graphs represent the means ± SDs.

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