Fig. 2: Mutation in the cancer hallmark genes and their functional relevance in T. annulata infected samples.
From: Genomic characterization of host gene alterations in Theileria annulata-transformed leukocytes
a The graph shows the total mutational burden of the 22 tier 1 gene (COSMIC) identified in our data using WGS analysis. Gene’s mutational burden was calculated individually in each sample and then averaged for the six samples. Both synonymous and non-synonymous mutations were calculated for all six samples and represented in the form of a box plot as the total mutational burden. Error bars represent the mean with standard deviation (SD). b Based on the COSMIC database, the Figure shows the list of cancer hallmark genes and their process linked. These 12 cancer hallmark genes are found to have common nonsynonymous mutations throughout the six samples in our data. These genes are shown to have roles as tumor activators or suppressors marked with purple and pink colors, respectively. c, d Lollipop images representing the distribution of mutations along with the SIFT score of KMT2C and ROS1 across six Theileria-infected cells. e q-PCR based gene expression levels of tumor suppressing genes in T. annulata cells w.r.t uninfected healthy PBMCs. Error bars represent the mean with standard deviation (SD).
