Fig. 5: Structural superposition of NBTI bound cocrystal structures. | Communications Biology

Fig. 5: Structural superposition of NBTI bound cocrystal structures.

From: Structural interactions of BWC0977 with Klebsiella pneumoniae topoisomerase IV and biochemical basis of its broad-spectrum activity

Fig. 5: Structural superposition of NBTI bound cocrystal structures.The alternative text for this image may have been generated using AI.

A The BWC0977 cocrystal structure with K. pneumoniae topoisomerase IV (PDB: 9KGT) is used as a template for structural alignment with B gepotidacin (PDB: 6QTK) and C compound 17a, (Roche, PDB: 7FVT) cocrystals with S. aureus gyrase. D The structures of BWC0977 and compound 17a are superposed to compare binding mode similarities and differences. The H-bond interactions between the compound and binding site residues are highlighted in black dashed lines, while the intra-molecular interactions between the binding site residues and with DNA are shown in red dashed lines. Chain identifiers are highlighted in parentheses.

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