Fig. 2: Social isolation during adolescence but not adulthood disrupts texture discrimination. | Communications Biology

Fig. 2: Social isolation during adolescence but not adulthood disrupts texture discrimination.

From: Adolescent stress remodels synapses in the sensory thalamus and impairs tactile discrimination in mice

Fig. 2

a Experimental flow. Male mice were used. b Trajectories of mice in the area during OFT. The area surrounded by a dashed line was where we measured the center time in (c). c Total distance mice traveled during the OFT (Adolescent: GH, N = 16; SI, N = 15; df = 29; t = −1.436; p = 0.162 by Student’s t-test; Adult: GH, N = 15; SI, N = 14; df = 27; t = −0.964; p = 0.343 by Student’s t-test). d Time spent in the center area during the OFT (Adolescent: GH, N = 16; SI, N = 15; df = 29; t = −1.596; p = 0.121 by Student’s t-test; Adult: GH, N = 15; SI, N = 14; df = 27; t = −0.619; p = 0.541 by Student’s t-test). e Discrimination index in the tNORT of adolescent GH or SI condition (GH, N = 16; between sessions: F(2, 30) = 9.341, p < 0.001 by one-way RM-ANOVA; Learning vs. Test 1: **p = 0.002; Learning vs. Test 2: **p = 0.002; Test 1 vs. Test 2, p = 0.876 by Holm-Sidak post-hoc test; SI, N = 14; between sessions: F(2, 26) = 4.816, *p = 0.017 by one-way RM-ANOVA; Learning vs. Test 1: p = 0.759; Learning vs. Test 2: *p = 0.026, Test 1 vs. Test 2: *p = 0.036 by Holm-Sidak post-hoc test). f Discrimination index in the NORT of adolescent GH or SI condition (GH, N = 16; df = 15; t = −3.745; **p = 0.002 by paired t-test; SI, N = 14; df = 13; t = −3.283; **p = 0.006 by paired t-test). g Discrimination index in the tNORT of adult GH or SI condition (GH, N = 13; between sessions: F(2, 24) = 8.653, p = 0.001 by one-way RM-ANOVA; Learning vs. Test 1: **p = 0.003; Learning vs. Test 2: **p = 0.004; Test 1 vs. Test 2: p = 0.753 by Holm-Sidak post-hoc test; SI, N = 13; between sessions: F(2, 24) = 10.653, ***p < 0.001 by one-way RM-ANOVA; Learning vs. Test1: **p = 0.001; Learning vs. Test 2: **p = 0.002; Test 1 vs. Test 2: p = 0.721 by Holm-Sidak post-hoc test). h Discrimination index in the NORT of adult GH and SI mice (GH, N = 13; df = 12; t = −5.883; ***p < 0.001 by paired t-test; SI, N = 13; df = 12; t = −5.405; ***p < 0.001 by paired t-test). Data from the same mouse are connected by gray solid (GH) or dashed (SI) lines. Vertical bars represent mean ± SEM (c–h).

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