Fig. 4: Adolescent SI rearing causes a transient elevation of corticosterone, and synapse remodeling occurs within the first week of the SI period. | Communications Biology

Fig. 4: Adolescent SI rearing causes a transient elevation of corticosterone, and synapse remodeling occurs within the first week of the SI period.

From: Adolescent stress remodels synapses in the sensory thalamus and impairs tactile discrimination in mice

Fig. 4

a, b Urinary corticosterone levels measured during GH or SI rearing starting at P21 (a, Adolescent GH, N = 12; Adolescent SI, N = 14; day 7, ***p < 0.001; day 14, p = 0.21; day 21, p = 0.198; day 28, p = 0.797 by U-test) and 8 weeks old (b, Adult GH, N = 8; Adult SI, N = 8; day 7, p = 0.959; day 14, p = 0.878; day 21, p = 0.083; day 28, p = 0.279 by U-test). Solid lines represent mean ± SEM. c Mice were weaned at P21 and reared under GH or SI conditions for 1 week (1w-GH, N = 4; 1w-SI, N = 3). d Representative MLF-VPM EPSC traces. e Histograms of afferent numbers (1w-GH, n = 44; 1w-SI, n = 46; ***p < 0.001 by U-test). d Plots of SF- and Max-amplitude (SF-amplitude: 1w-GH, n = 58; 1w-SI, n = 99; ***p < 0.001 by U-test; Max-amplitude: 1w-GH, n = 44; 1w-SI, n = 46; p = 0.475 by U-test). Scale bars: 5 ms, 1 nA. Vh = −70 mV. Each point in f represents the amplitude of an individual fiber and VPM neuron, respectively. Boxes indicate mean values with error bars showing ± SEM (f). Data from different mice were shown using distint symbols (e, f). All data were obtained from male mice.

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