Fig. 7: Remodeling at VPM synapses after a 1-week adolescent SI is partially normalized by 4-weeks of cohabitation with a male GH- mouse. | Communications Biology

Fig. 7: Remodeling at VPM synapses after a 1-week adolescent SI is partially normalized by 4-weeks of cohabitation with a male GH- mouse.

From: Adolescent stress remodels synapses in the sensory thalamus and impairs tactile discrimination in mice

Fig. 7

a Male mice were kept unser SI conditions from P21 for 4 weeks (4w-SI). A male GH mouse was then introduced into SI mouse’s cage and cohabited for 4 weeks (4w-CH) (4w-SI + 4w-CH, N = 4; 4w-SI + 4w-SI, N = 3). b Representative MLF-VPM EPSCs traces in each condition. c Histograms of afferent numbers (4w-SI + 4w-SI, n = 37; 4w-SI + 4w-CH, n = 43; p = 0.103 by U-test). d Plots of SF- and Max-amplitudes (SF-amplitude: 4w-SI + 4w-SI, n = 78; 4w-SI + 4w-CH, n = 80; p = 0.776 by U-test; Max-amplitude: 4w-SI + 4w-SI, n = 37; 4w-SI + 4w-CH, n = 43; p = 0.300 by U-test). e Male mice were kept in SI conditions for 1 week (1w-SI), then cohabited with a male GH mouse for 4 weeks (4w-CH) (1w-SI + 4w-SI, N = 4; 1w-SI + 4w-CH, N = 4). f Representative traces of MLF-VPM EPSCs in each condition. g Histograms of afferent numbers (1w-SI + 4w-SI, n = 44; 1w-SI + 4w-CH, n = 38; *p = 0.042 by U-test). h Plots of SF- and Max-amplitudes (SF-amplitude: 1w-SI + 4w-SI, n = 111; 1w-SI + 4w-CH, n = 75; *p = 0.018 by U-test; Max-amplitude: 1w-SI+4w-SI, n = 44; 1w-SI+4w-CH, n = 38, p = 0.838 by U-test). Scale bars: 5 ms, 1 nA. Vh = −70 mV. Each point in d, h represents the amplitude of individual fiber and VPM neuron, respectively. Boxes represent mean values with error bars showing ± SEM (d, h). Data from different mice are shown using distinct colors (c, d, g, h).

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