Fig. 4: Metabolic effects (n = 20 participants). | Communications Biology

Fig. 4: Metabolic effects (n = 20 participants).

From: Neural and molecular changes during a mind-body reconceptualization, meditation, and open label placebo healing intervention

Fig. 4: Metabolic effects (n = 20 participants).

A–C Seahorse XF analyzer real time cellular metabolic assays with BE(2)M17 human neuroblastoma cells treated with 1% pre- and post-retreat plasma for 60-min or assay buffer (control). Mean ± 95% CI error bars. A ATP production rate assay with total ATP production rate (mean ± 95% CI) broken into glycolytic and mitochondrial ATP production rates. B Glycolytic rate assay, including basal and compensatory glycolytic rates (top) and basal mitochondrial respiration rate (bottom). Mean ± 95% CI error bars. C Mitochondrial respiration stress assay. Mean ± 95% CI error bars. Asterisks denote * (p < 0.05), ** (p < 0.01), *** (p < 0.001), **** (p < 0.0001). D Glycolysis pathway index pre-to-post fold change. Error bars denote SEM. Index fold change levels significantly above zero signal an upregulated pathway or protein cluster. E Glycolysis pathway heat map. Fold change level per component protein for advanced and novice participants. F, G Oxidative phosphorylation pathway index with pre-to-post fold change (F) and heat map for advanced and novice participants (G). Error bars denote SEM.

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