Fig. 6: cell–cell communication among Glutamatergic neurons, astrocytes and oligodendrocytes.

A Circle plot showing a differential number of interactions between Glutamatergic neurons, astrocytes, and oligodendrocytes under M vs S. Red (or blue) colored edges represent increased (or decreased) signaling in the comparison. B Circle plot showing differential number of interactions between Glutamatergic neurons, astrocytes, and oligodendrocytes under MP+M. C Overall information flow of top signaling pathway from Glutamatergic neuron to astrocytes and oligodendrocytes under M vs S. D Overall information flow of top signaling pathway from Glutamatergic neuron to astrocytes and oligodendrocytes under MP+M. M vs S, morphine vs saline. MP+M, morphine +probiotics vs morphine. See also Fig. S7.