Fig. 1: Genome-wide association analysis for age at onset in Japanese patients with amyotrophic lateral sclerosis (ALS).
From: A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS
a Manhattan plot for age at onset in patients with ALS in the discovery cohort (n = 1808). The horizontal gray line represents the genome-wide significance level (α = 5 × 10−8). Loci significantly associated with the age at ALS onset are highlighted in red. One locus (4q34.2) showed a genome-wide significance. b Manhattan plot of the meta-analysis of the age at onset in Japanese patients with ALS. We combined the results from the discovery (n = 1808) and replication (n = 207) cohorts in a meta-analysis (total n = 2015 independent patients). The meta-analysis confirmed the genome-wide significance of the single-nucleotide polymorphisms (SNPs) at the 4q34.2 locus, with the leading SNP being rs113161727. c Regional association plots for the 4q34.2 locus identified in the genome-wide meta-analysis (n = 2015). The vertical axis represents −log10 (p-value) for assessing the association between each SNP and age at onset. Colors indicate the linkage disequilibrium (r2) between each sentinel SNP and neighboring SNPs based on the JPT population of the 1000 Genomes Project phase 3. JPT Japanese people in Tokyo, Japan.
