Fig. 2: Distribution of age at onset (AAO) and the relationship between AAO and rs113161727 in Japanese patients with amyotrophic lateral sclerosis (ALS).
From: A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS
a Distribution of AAO in the discovery cohort (n = 1808). b Distribution of AAO in the discovery cohort according to the rs113161727 genotype. Patients with the AG or AA genotype of rs113161727 showed a younger AAO distribution than those with the GG genotype. AAO < 40 years was 11.8% in patients with the AG or AA genotype, compared to 5.3% in those with the GG genotype. The AAO ≥ 70 years was 17.7% in patients with the AG or AA genotype, compared with 29.7% in those with the GG genotype. c Relationship between AAO and rs113161727 in the discovery cohort (n = 1808). d Relationship between AAO and rs113161727 in patients with ALS with a SOD1 mutation (n = 65). The bottom and top of the box indicate the interquartile ranges (25th and 75th percentiles), and the line represents the median. Whiskers under and over the box correspond to a 1.5× interquartile range, and circles indicate outliers.
