Fig. 3: Forest plots of the association between rs113161727 and the site of onset.
From: A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS
Forest plot shows odds ratios (ORs) with 95% confidence intervals (CIs) for the A allele of rs113161727 in relation to the site of onset. The analyses were conducted using the discovery cohort, which included 1658 patients with available clinical data. N (+) indicates the number of patients with the onset site, and N (−) indicates the number of patients without the onset site. Black squares represent the OR, and dashed horizontal error bars indicate the 95% CI. The vertical gray line indicates OR = 1. The A allele of rs113161727 significantly increased the risk of lower limb onset (p = 0.005) and tended to decrease the risk of bulbar onset (p = 0.048) but did not affect upper limb onset. OR odds ratio, 95% CI 95% confidence interval.
