Table 1 Genomic region and lead SNP for the age at onset of patients with ALS

From: A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS

SNP

Chr

Position

Gene

Alleles

Group

EAF

Effect

SE

p-value

I2

HetPVal

Non-effect

Effect

rs113161727

4

176385733

ADAM29, GPM6A

G

A

Discovery cohort

0.084

−4.271

0.782

4.60 × 10−8

  
      

Replication cohort

0.085

−5.104

1.867

6.81 × 10−3

  
      

Meta-analysis

0.084

−4.395

0.721

1.08 × 10−9

0

0.681

  1. Position is based on Human Genome Assembly build 37. Gene symbols are shown in italics.
  2. SNP single-nucleotide polymorphism, Chr chromosome, EAF effect allele frequency, SE standard error, HetPVal p-value from the test of heterogeneity.
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