Fig. 4: Functional mechanisms associated with changes in the microbiome of 3xTg-AD mice fed with MCT or KD for 1 month. | Communications Biology

Fig. 4: Functional mechanisms associated with changes in the microbiome of 3xTg-AD mice fed with MCT or KD for 1 month.

From: Medium-chain triglycerides and ketogenic diet prevent alterations of the gut microbiome in transgenic Alzheimer’s disease mice

Fig. 4: Functional mechanisms associated with changes in the microbiome of 3xTg-AD mice fed with MCT or KD for 1 month.The alternative text for this image may have been generated using AI.

a Principal Component Analysis (PCA) of each mouse microbiome according to Metacyc predicted pathways abundance obtained with PICRUST analysis. b Heatmap of Metacyc pathways with significant differential abundance across groups (ALDEx2 Kruskal-Wallace, adjusted P < 0.05). c Heatmap of KEGG pathways with significant differential abundance across groups (ALDEx2 Kruskal-Wallace, adjusted P < 0.05). The pathways were classified into 3 groups based on dendrogram and their abundance: group (1) pathways enriched in 3xTg-AD mice compared to WT mice on Control diet and reduced by MCT or KD, group (2) pathways reduced or unaltered in 3xTg-AD mice compared to WT mice on Control diet and increased by MCT or KD and group (3) pathways altered in 3xTg-AD mice with no diet effect. d Heatmap of Pearson correlation between ASVs and predicted functional pathways of group (1). e Heatmap of Pearson correlation between ASVs and predicted functional pathways associated with SCFA metabolism in group (2). For d, e asterisks indicate ASVs or pathways engaged in multiple correlations.

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