Fig. 4: Sibanin modulates NaV1.7 channel gating dynamics.
From: Dual-action salivary peptide drives black fly feeding efficiency
a Representative current traces collected before (gray) and after perfusion (red) of 200 nM sibanin on HEK293T cell expressing NaV1.7 channel. b Average current vs voltage relationship for the traces as in A (n = 3). c Average conductance–voltage relationship of sibanin acting on NaV1.7 channel (n = 3). d Effect of 200 nM sibanin on the fast inactivation (n = 3). e Effect of sibanin on the recovery from fast inactivation. f Plot for sibanin inducing use-dependent inhibition. Currents were normalized to the first-pulse current in the absence (gray) or presence (red) of 200 nM sibanin and plotted against the pulse number (n = 3). Data were expressed as mean ± SEM.
