Fig. 1: Network-specific cubic trajectories of corpus callosum tract density across the adult lifespan. | Communications Biology

Fig. 1: Network-specific cubic trajectories of corpus callosum tract density across the adult lifespan.

From: Network-specific corpus callosum aging and age-moderated cognitive associations using tract-to-region analysis

Fig. 1

Each point represents an individual participant’s harmonized tract density value (N = 718, ages 36–100 years). Solid lines show cubic polynomial model fits for each of the seven functional networks: Visual (Vis), Somatomotor (SomMot), Dorsal Attention (DorsAttn), Salience/Ventral Attention (SalVentAttn), Limbic, Control (Cont), and Default Mode (Default). Five networks show significant cubic effects (FDR q < 0.05, indicated by *), characterized by relative stability in early-middle adulthood followed by accelerated decline. The Limbic network shows a distinct positive trajectory, while the Visual network remains essentially flat. Shaded regions represent 95% confidence intervals.

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