Fig. 1: Defining clusters of canine thyroid carcinoma. | Communications Biology

Fig. 1: Defining clusters of canine thyroid carcinoma.

From: Comparative genomic and clinicopathological analysis uncovers contrasting molecular profiles of canine and human thyroid carcinomas

Fig. 1

A A set of 1013 genes with highly variable expression levels across thyroid tumor and normal samples were used for UMAP clustering. Each point represents an individual sample positioned in a two-dimensional space according to its transcriptomic profile. Samples are colored by their cluster ID and shaped by the histologic pattern defined by the pathologist, illustrating concordance between molecular clustering and histopathologic classification. B Heatmap of thyroid cell type markers: calcitonin A and B (CALCA and CALCB) and NKX2-1 transcripts. The samples with high calcitonin transcript levels also had positive calcitonin IHC staining with exception of TC1020 sample. The loss of thyroid-related transcription factor (NKX2-1) transcript was observed in TC1088 sample.

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